The Radiotherapy with Methotrexate, Vinblastine, Doxorubicin, and Cisplatin Treatment Is an Effective Therapeutic Option in Patients with Advanced or Metastatic Bladder Cancer
スポンサーリンク
概要
- 論文の詳細を見る
The objectives of this study were to determine the tolerability of combined use of methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) with external beam radiation therapy (EBRT) and to access the efficacy in patients with locally advanced or metastatic bladder cancer. From December 2000 to November 2010, 30 eligible patients were enrolled in this study. After receiving one cycle of MVAC treatment, all patients received EBRT with a half dose of MVAC treatment followed by two more cycles of chemotherapy. A standard fractionation with daily dose of 1.8–2.0 Gy was used, with the total dose up to 60 Gy over 5–6 weeks. The four-field box technique was utilized for radiation fields. Thirteen patients (43%) had complete response and 11 (37%) had partial response, with an overall response rate of 80%. The median overall survival and progression-free survival was 25.5 months and 12.8 months, respectively. In the complete-response patients, median overall survival was 37.1 months. Grade 3 or 4 neutropenia occurred in 25 patients (83%), but there were no severe infections. One patient (3%) had hemorrhagic radiation cystitis. There were no treatment-related deaths. Combined use of MVAC treatment with EBRT is a favorable therapeutic option for patients with advanced or metastatic bladder carcinoma. Given the safety and benefit profile found in this study, appropriate case selection is warranted in the future.
- Journal of Radiation Research 編集委員会の論文
著者
-
Matsumoto Kazumasa
Department Of Urology Kitasato University School Of Medicine
-
Baba Shiro
Department Of Pediatrics Graduate School Of Medicine Kyoto University
-
Satoh Takefumi
Department Of Urology Kitasato University
-
Ikeda Masaomi
Department Of Applied Physics Faculty Of Engineering Hiroshima University
-
ISHIYAMA Hiromichi
Department of Radiation Oncology, Kitasato University School of Medicine
-
Niibe Yuzuru
Department Of Radiology Kitasato University School Of Medicine
-
Matsushita Kazuhito
Department Of Radiology Kitasato University School Of Medicine
-
Hayakawa Kazushige
Department Of Experiment Radiology Oncology The University Of Texas M. D. Anderson Cancer Center
-
Kitano Masashi
Department Of Radiology Kitasato University School Of Medicine
-
Fujita Tetsuo
Department Of Electronic Engineering Shizuoka Institute Of Science And Technology
-
Matsumoto Kazumasa
Department Of Urology Kitasato University Hospital
-
Iwamura Masatsugu
Department Of Urology Kitasato University Hospital
-
KOTANI Shoko
Department of Radiology and Radiation Oncology, Kitasato University School of Medicine
関連論文
- The Relation of Radiation Dose to Acute Skin Reaction as Measured by Electrical Skin Conductivity (Original)
- Five years experience of transrectal high-intensity focused ultrasound using the Sonablate device in the treatment of localized prostate cancer
- PE-454 Cell Line-dependent Differentiation of Mouse Induced-pluripotent Stem Cells into Cardiomyocytes(PE076,Regeneration (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-272 Cyclin-dependent kinases-9 is required for the differentiation of mouse ES cells into cardiac myocytes.(Development and differentiation(02)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-760 Cyclin-Dependent Kinases-9, as a Novel Component of p300/GATA-4 Complex, is Involved in Differentiation of Mouse ES Cells into Cardiac Myocytes(Development and differentiation-2, The 71st Annual Scientific Meeting of the Japanese Circulation Societ
- DNA hypermethylation and histone hypoacetylation of the HLTF gene are associated with reduced expression in gastric carcinoma
- The value of γ-seminoprotein in combination with prostate specific antigen in detecting prostate cancer
- The Clinical Effectiveness of Laser-Lithotripsy for Ureteral Calculi with an Automatic Stone Detection System
- Ammonium acid urate urolithiasis in Japan
- High-dose rate iridium-192 brachytherapy boost to external beam radiation therapy for prostate cancer in Japanese men
- Gemcitabine and paclitaxel chemotherapy as a second-line treatment for advanced or metastatic urothelial carcinoma
- Laparoscopic radical cystectomy and bilateral ureteric ligation for muscle-invasive bladder cancer in a patient on hemodialysis
- Considerably frequent coexistence of malignant characteristics in urothelial inverted tumors
- Laparoscopic pyeloplasty for ureteropelvic junction obstruction : Outcome of initial 12 procedures
- Increased expression of the mts1 gene in urogenital cancers
- An Application of the Fluorescence Differential Display Method to Clone Genes Related to Prostate Cancer
- Sufficient prophylactic efficacy with minor adverse effects by intravesical instillation of low-dose bacillus Calmette-Guerin for superficial bladder cancer recurrence
- Reclassification of the current tumor, node, metastasis staging in pT3 renal cell carcinoma
- Long-term results of three different minimally invasive therapies for lower urinary tract symptoms due to benign prostatic hyperplasia : Comparison at a single institute
- Long-term effects of transurethral microwave thermotherapy
- Differential Diagnosis of Primary Benign and Malignant Retroperitoneal Tumors
- TREATMENT OF BENIGN PROSTATIC HYPERPLASIA WITH HIGH INTENSITY FOCUSED ULTRASOUND: AN INITIAL CLINICAL TRIAL IN JAPAN WITH MAGNETIC RESONANCE IMAGING OF THE TREATED AREA
- High Intensity Focused Ultrasound for Benign Prostatic Hyperplasia; A 6-month Follow-up
- A NEW SCORING SYSTEM BASED ON THE HISTOLOGICAL BEHAVIOR AND PROLIFERATIVE ACTIVITY OF TUMOR CELLS FOR GRADING THE MALIGNANT POTENTIAL OF BLADDER CANCERS
- Transurethral Microwave Hyperthermia of Benign Prostatic Hyperplasia
- Laparoscopy-Assisted Pyeloplasty
- Burden of male stress urinary incontinence : A survey among urologists in Japan
- Guidelines for urological laparoscopic surgery
- Current use of the artificial urinary sphincter and its long-term durability : A nationwide survey in Japan
- The difference in therapeutic effect of transurethral microwave thermotherapy between prostate cancer and benign prostatic hyperplasia
- Cavernous hemangioma of the adrenal gland
- Multicentric hyaline-vascular Castleman's disease treated by laparoscopic resection
- Laparoscopy Assisted Orchiopexy : Technical Feasibility and Indications
- S9-1 Current status of immunotherapy with cytokines and allogeneic hematopoietic cell trasplantation for metastatic renal cell carcinoma(Symposium 9「Recent Trend of Treatment for Metastatic Renal Cell Carcinoma」)
- Quality of life after laparoscopic or open radical prostatectomy : interim report on multi-institutional longitudinal study in Japan
- Retroperitoneal extragonadal germ cell tumor presenting as a bulky pelvic mass of the obturator fossa
- Surgical outcome of laparoscopic radical prostatectomy : summary of early multiinstitutional experience in Japan
- Simple Technique to Visualize Random Set-up Displacements Using a Commercially Available Radiotherapy Planning System
- Extracorporeal shock wave treatment for Peyronie's disease using EDAP LT-02 ; preliminary results
- Topographic anatomy of the male perineal structures with special reference to perineal approaches for radical prostatectomy
- DNA-based identification resolved suspected misdiagnosis due to contaminated cytological specimens
- A Japanese propositus with D-- phenotype characterized by the deletion of both the RHCE gene and D1S80 locus situated in chromosome 1p and the existence of a new CE-D-CE hybrid gene
- Giant Retroperitoneal Cyst in an Adult Male
- Interactive-plan technique conquers the disadvantages of volume-reducing hormone therapy in ^I permanent implantation for localized prostate cancer
- Needle position during ^I seed implantation : accurately recognized by sagittal transrectal ultrasonography
- Searching for new biomarkers of bladder cancer based on proteomic analysis
- 2P446 Proteomio analysis for urine samples(48. Bioinformatics, genomics and proteomics (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
- 2P445 High-molecular-mass proteome analysis of prostate cancer by agarose 2-DE and LC-MS/MS(48. Bioinformatics, genomics and proteomics (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
- 2P443 Renal cell carcinoma proteomics by agarose two-dimensional gel electrophoresis and LC-MS/MS(48. Bioinformatics, genomics and proteomics (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
- Computer simulated additional deep apical biopsy enhances cancer detection in palpably benign prostate gland
- Thoracoscopic transdiaphragmatic adrenalectomy for isolated locally recurrent adrenal carcinoma
- Efficacy and morbidity of transrectal ultrasound-guided 12-core biopsy for detection of prostate cancer in Japanese men
- Prostatic cystadenoma presenting as a large multilocular mass
- Treatment outcome by risk group after radical prostatectomy in Japanese men
- Early Complications and Morbidity after Radical Prostatectomy in Japan : The Kitasato Experience
- Anderson-Hynes 法による腹腔鏡下腎盂形成術 : 簡単・確実に施行するためのコツと工夫
- Ureteral obstruction due to retroperitoneal fibrosis secondary to a solitary internal iliac aneurysm
- F-Aggregation of Reactor-Irradiated NaCl Crystals
- Difference in Prognostic Factors between Stage IB and II Uterine Cervical Carcinoma Patients Treated with Radical Hysterectomy and Postoperative Radiation Therapy
- Java Birthmarks : Detecting the Software Theft(Application Information Security)
- A Visual Framework for Monitoring and Controlling Distributed Service Components (日韓合同ワークショップ 1st Korea-Japan Joint Workshop on Ubiquitous Computing and Networking Systems (ubiCNS 2005))
- Weekly paclitaxel plus estramustine combination therapy in hormone-refractory prostate cancer:A pilot study
- Usefulness of tamsulosin hydrochloride and naftopidil in patients with urinary disturbances caused by benign prostatic hyperplasia : A comparative, randomized, two-drug crossover study
- Nocturnal enuresis and overactive bladder in children : An epidemiological study
- Combined effect of clarithromycin and imipenem/cilastatin against urinary biofilm infection after pyeloplasty
- Endoscopic treatment of a long fibroepithelial ureteral polyp
- Anterior urethral valves in children : A possible association between anterior urethral valves and Cowper's duct cyst
- Renal silica calculi in an infant
- Endoscopic removal of intravesical thermometer using a rigid nephroscope and forceps
- Nomogram to predict seminal vesicle invasion using the status of cancer at the base of the prostate on systematic biopsy
- The clinical significance of urine cytology after a radical cystectomy for urothelial cancer
- Clinical guidelines for nocturia
- Retroperitoneoscopic ureterolithotomy for impacted ureteral stone
- Squamous cell carcinoma of the ranal pelvis with inferior vena caval extension
- Transurethral Microwave Thermotherapy for Benign Prostatic Hyperplasia; Comparison of Different Treatment Protocols
- Malignant mesothelioma of testicular tunica vaginalis
- Delayed recovery of urinary continence after laparoscopic radical prostatectomy
- L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer
- DNA methylation of multiple genes in gastric carcinoma : Association with histological type and CpG island methylator phenotype
- Minimally invasive surgery using ablative modalities for the localized renal mass
- Lower urinary tract symptoms and risk of prostate cancer in Japanese men
- Molecular characteristics of differentiated-type gastric carcinoma with distinct mucin phenotype : LI-cadherin is associated with intestinal phenotype
- Gemcitabine and cisplatin chemotherapy induced reversible posterior leukoencephalopathy syndrome in a bladder cancer patient
- Profilin 1, overexpression in renal cell carcinoma
- The Radiotherapy with Methotrexate, Vinblastine, Doxorubicin, and Cisplatin Treatment Is an Effective Therapeutic Option in Patients with Advanced or Metastatic Bladder Cancer
- Erectile function and nocturnal penile tumescence in patients with prostate cancer undergoing luteinizing hormone-releasing hormone agonist therapy
- Transurethral Management of Ureteral Calculi with Rigid Ureteroscope
- Results of a Questionnaire Survey for Symptom of Late Complications Caused by Radiotherapy in Breast Conserving Therapy
- Geometrical Verification System Using Adobe Photoshop^【○!R】 in Radiotherapy
- Impact of Pretreatment Cholinesterase Level on Survival of Inoperable Intrahepatic or Hepatic-hilar Carcinomas Treated with Three-dimensional Conformal Radiotherapy
- Elimination of IL-13 Reverses Established Goblet Cell Metaplasia into Ciliated Epithelia in Airway Epithelial Cell Culture
- The Radiotherapy with Methotrexate, Vinblastine, Doxorubicin, and Cisplatin Treatment Is an Effective Therapeutic Option in Patients with Advanced or Metastatic Bladder Cancer
- Radiotherapy quality assurance of the Japanese Gynecologic Oncology Group study (JGOG1066) : a cooperative phase II study of concurrent chemoradiotherapy for uterine cervical cancer
- Effect of light units on tooth bleaching with visible-light activating titanium dioxide photocatalyst
- Guidelines for Smoking Cessation (JCS 2010) : Digest Version
- Advancements in Urology 2011 : A Japanese Urological Association (JUA)/American Urological Association (AUA) Symposium
- Genome-wide transcriptome analysis of fluoroquinolone resistance in clinical isolates of Escherichia coli
- High-intensity focused ultrasound therapy for prostate cancer
- Immunohistochemical biomarkers for bladder cancer prognosis
- EORTC QLQ-BM22 and QLQ-C30 quality of life scores in patients with painful bone metastases of prostate cancer treated with strontium-89 radionuclide therapy