ビタミンEの生命科学 (脂質の生命科学<特集>) -- (脂溶性ビタミン)

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Vitamin E has been established from the experimental results that unknown substance contained in lettuce prevented fetal reabsorption in rats who fed synthetic diets including the vitamins previously found. Then, the multiplicity of severe pathological reactions that could be obtained in animals when vitamin E was removed from their diets, presents a confusing picture that is difficult to relate to human disorders. Recently, careful clinical studies of individuals with low plasma tocopherol levels together with trials of therapy have clarified the clinical situations and physical features which can be attributed to vitamin E deficiency. There have been three categories in the human vitamin E deficiency : (1) premature infants, (2) fat-malabsorption syndrome, and (3) isolated vitmain E deficient neuropathy. Free radical reactions, ubiquitous in living systems, which are of both enzymatic and non-enzymatic origin, may chemically explain the clinical changes relating to diseases. Biological scavenge systems and substances for protecting the progressive radical chain reactions exist in living systems. Vitamin E as a nutrients for scavenging the chain, may play an important role in maintaining health. In this paper, the scavenging action of vitamin E contained in erythrocyte membranes has been shown as a model, that radical reactants are introduced in biological system. Introduced radicals in erythrocyte membranes were used a xanthine oxidase reaction and an azo compound, AAPH, which are known to produce superoxide anions and hydroperoxides, respectively. In addition, erythrocyte tocopherol levels are shown to be clinically available for the assessment of nutritional status of vitamin E.
日本油化学会の論文

ビタミンEの生命科学 (脂質の生命科学<特集>) -- (脂溶性ビタミン)

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