一酸化炭素とシアンイオンの細胞内呼吸に及ぼす共同作用

概要

論文の詳細を見る
The combined effect of carbon monoxide (CO) and cyanide has been a controversial issue. To elucidate the interaction of CO and cyanide, the fluorescence which represents the intracellular reduced pyridine nucleotide was measured on the rabbit kidney surface in situ. Various doses of potassium cyanide (KCN), 2μmol/kg-8μmol/kg, were administered intravenously with and without inhalation of 1, 2, and 3% CO via a respirator. The dose-response relationship between KCN and the fluorescence increase fitted a salient sigmoid curve with a steep slope, and CO was potent to increase fluorescence independently and shifted the dose-response curve for KCN to the left. It was concluded that the combined effect of CO and KCN was additive, but when cyanide was of a critical dose for intracellular respiration, it had the appearance of synergism.
日本衛生学会の論文