一酸化炭素の生体臓器の組織呼吸に及ぼす影響

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The effect of carbon monoxide (CO) on the tissue respiration was studied in the renal cortex of the rabbit using the fluorometric method which has been developed for the determination of reduction of intracellular pyridine nucleotide component.Blood Po2 of the renal artery and vein was measured with a gas analyzer, and the renal blood flow was examined with a electromagnetic flowmeter.The redox state of the renal cortical surface was altered by the CO inhalation of 0.5%, 1%, 2% and 3%, or the exposure to hypoxic hypoxia.Even when considering the Haldane effect, CO hypoxia caused a increase in fluorescence response at milder hypoxidosis that caused by the exposure to hypoxia, and developed the characteristic slope of the fluorescence increment which was not observed during the exposure to hypoxia.Varying the CO and oxygen concentrations in the inhaled gas, it was demonstrated that there were dose-response relationships between the redox state of the renal tissue and the CO concentration or the oxygen concentration in the inspired gas.The prolonged exposure to CO resulted in a slow decrease in the renal blood flow, while the exposure to hypoxia showed a more rapid and marked decrease in blood flow.Some implications of hystotoxic properties of CO were discussed from toxicological points of view on the results obtained, and it was suggested that CO had the direct effect on the respiratory chain when the blood contained COHb over approximately 18.3%, and the histotoxic property appeared to play an important role in the CO toxicity at COHb levels over 31.2%.
日本衛生学会の論文

一酸化炭素の生体臓器の組織呼吸に及ぼす影響

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