慢性カドミウム中毒の臨床化学的研究 : (第4報) アミノ酸尿

概要

論文の詳細を見る
Urine specimens were collected from 40 actual and 17 suspected Itai-itai disease patients living in the cadmium-polluted Jinzu River basin, from 56 subjects with renal tubular damage living in the Kakehashi River basin polluted by cadmium and from 10 subjects from non-polluted areas. The urine was analyzed for individual free amino acids, total protein, glucose, β2-microglobulin, retinol binding protein, lysozyme and cadmium quantitatively.Generalized aminoaciduria was found in both the actual and suspected patients and also in those inhabitants of the Kakehashi River basin.Amino acid patterns were very similar among all specimens though the excreted amounts of amino acid were lower in the urine of the inhabitants in the Kakehashi River basin.High correlation coefficients were found between the excretion of individual amino acids (alanine, proline, ornithine) and other substances (total protein, glucose, β2-m, RBP, lysozyme), and also between urinary amino acids and renal functions (Ccr, CPAH, % TRP).The results indicate that the aminoaciduria mechanism in chronic cadmium poisoning is due to multiple disorders of amino acid transport in renal tubules, and that urinary amino acids peculiar to Itai-itai disease do not exist.