慢性カドミウム中毒の臨床化学的研究 : (第2報) 血液検査成績

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The study covered 40 Itai-itai disease patients, 61 suspected patients and 9 inhabitants of Tsushima Island. These people were considered to be heavily damaged by cadmium. The reference group was comprised of 27 inhabitants in a nonpoulluted area.Blood specimens were collected from the people and examined biochemically.Itai-itai disease patients showed low levels of plasma inorganic phosphorous, potassium, total protein and uric acid. They also showed high levels of sodium, chloride, GOT, alkaline phosphatase, LDH, BUN and creatinine.No significant differences in the blood findings, except for alkaline phosphatase and total protein, were observed between the patients with Itai-itai disease and suspected patients.The inhabitants of Tsushima Island showed the same abnormal tendency for blood findings as did the Itai-itai disease patients.We concluded that the abnormal blood findings of Itai-itai disease patients were common among inhabitants of cadmium-polluted areas and that they give an advanced picture of chronic cadmium poisoning.
日本衛生学会の論文