慢性カドミウム中毒の臨床化学的研究(3)貧血

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The study covered 40 Itai-itai disease patients and 61 suspected patients who were considered to be heavily damaged by cadmium. The reference group was comprised of 27 inhabitants in a nonpolluted area.Blood specimens were collected, and the erythrocyte counts, hemoglobin and hematocrit values were measured. Blood and urine were also examined biochemically. Erythrocyte counts, hematocrit and hemoglobin values decreased significantly in the Cd-exposed groups. The mean M.C.H., M.C.V. and M.C.H.C. were higher in the Cd-exposed groups than in the reference group.Significant correlation coefficients in the Cd-exposed groups were observed between the erythrocyte counts and abnormal blood or urine, e.g. Cd, RBP, β2-microglobulin and lysozyme in the urine and creatinine, BUN, total protein, uric acid, alkaline phosphatase, TRP%, LDH and iron in the plasma.The correlation coefficients between the erythrocyte counts and the levels of creatinine and BUN in plasma were -0.61 and -0.50, respectively.We concluded that anemia in patients with or suspected of having Itai-itai disease is not hypochromic nor microcytic. Renal damage caused by cadmium exposure may be one of the factors that cause the anemia.