慢性カドミウム中毒の臨床化学的研究 : (第1報) 尿検査成績

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The study coverd 45 Itai-itai disease patients, 71 suspected patients and 81 inhabitants in three cadmium-polluted areas.These people were considered to be heavily damaged by cadmium.The reference group was comprised of 82 inhabitants in nonpolluted areas.Spot urine samples were collected and analysed for specific gravity, creatinine, amino-N, proline, total protein, glucose, calcium, phosphorous, cadmium, β2-microglobulin, retinol binding, protein and lysozyme.Itai-itai disease patients had high excretions of total protein, glucose, amino-N, proline, calcium, cadmium and low-molecular weight protein (β2-m., R.B.P. and lysozyme). The Ca/P ratio in urine was highest in patients with Itai-itai disease.There were no significant differences in the urinary findings between Itai-itai disease patients and suspected patients.The inhabitants in the three cadmium-polluted areas showed the same abnormal tendency for urinary findings as did the patients with Itai-itai disease.We concluded that the abnormal urinary findings of Itai-itai disease patients are common among the inhabitants of cadmium-polluted areas and give an advanced picture of chronic cadmium poisoning.