Some Properties of Thyroidal Membrane Adenosinetriphosphatase and Iodide Uptake: Effects of Basic Polyamino Acids
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概要
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Poly L-lysine, poly L-ornithine, and histone significantly inhibited the iodide uptake by the thyroid slices, as previously reported. These basic polymers diminished Na, K-ATPase and concomitantly markedly elevated Mg-ATPase activity in the Nal-treated microsomal preparation and the plasma membrane fraction obtained from thyroid. Poly L-glutamic acid, which was noneffetive to the iodide uptake <I>in vitro</I>, did not show such phenomenon. K-dependent p-nitrophenylphosphatase activity which is considered to reflect the terminal step of the reaction sequence of Na, K-ATPase was also inhibited by poly L-lysine. The effects mentioned above of poly L-lysine and other basic polyamino acids on membrane ATPase system were only found in the preparations from thyroid. The inhibitory effect of these reagents on thyroidal iodide uptake was discussed in terms of the change in membrane ATPase activities.
- 社団法人 日本内分泌学会の論文
著者
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YOSHIMURA YOSHIYUKI
Department of Biochemistry, Faculty of Pharmaceutical Sciences, The University of Tokushima
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KAWADA JUN
Department of Biochemistry, Faculty of Pharmaceutical Sciences, The University of Tokushima
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Minami Takeshi
Department Of Biotechnology Graduate School Of Engineering Osaka University
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Yoshimura Yoshiyuki
Department Of Biochemistry Faculty Of Pharmaceutical Sciences The University Of Tokushima
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YOSHIMURA Yoshiyuki
Department of Biochemistry, Faculty of Pharmaceutical Sciences, University of Tokushima
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MINAMI TAKESHI
Department of Biochemistry, Faculty of Pharmaceutical Sciences, University of Tokushima
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