No Reduction of Blood Glucose in Diabetic Rats after Oral Administration of Insulin Liposomes Prepared under Acidic Conditions
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概要
- 論文の詳細を見る
Insulin liposomes (dipalmitoyl phosphatidylcholine or dimyristoyl phosphatidylcholine/cholesterol=7/2) were prepared under strongly acidic conditions maintaining the biological activity of insulin. Although these were apparently noncharged liposomes, the association of insulin with membrane of liposomes was unexpectedly very large, and the uptake % of insulin was high. The distribution of vesicle-size of liposomes was narrow; the average diameter was 0.1 μm and no multilayered structures were observed by electron microscopy. Oral administration of the insulin liposomes (15- 30 IU/rat) in streptozotocin-diabetic rats did not result in any distinct tendency to reduce the level of blood glucose.
- 社団法人 日本内分泌学会の論文
著者
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Tanaka Naoko
Department Of Obstetrics And Gynecology Institute Of Health Biosciences The University Of Tokushima
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KAWADA JUN
Department of Biochemistry, Faculty of Pharmaceutical Sciences, The University of Tokushima
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Nozaki Yuji
Department Of Applied Microbial Technology The Kumamoto Institute Of Technology
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NOZAKI YUJI
Department of Biochemistry, Faculty of Pharmaceutical Sciences, University of Tokushima
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