Norepinephrine Induces Releases of Both LH-RH from the Hypothalamus and LH from the Rat Pituitary <I>in vitro.</I>

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概要

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• The effects of norepinephrine (NE) on the release of luteinizing hormone (LH) and LH-releasing hormone (LH-RH) were examined in a sequential double chamber perifusion system by perifusing the medio-basal hypothalamus (MBH) and/or pituitaries excised from normal female rats in diestrus. When the pituitary alone or in sequence with the MBH was perifused with medium containing 200μg/ml of NE, the concentration of LH in the efflux was significantly (p<0.05) increased to the level 50-150 % over the pre-injection control, whereas medium without NE had no effect. Perifusion of the pituitary in sequence with the MBH produced a higher peak level of LH than that attained by the perifusion of the pituitary alone. Administration of NE induced a significant increase in LH-RH release from the MBH, although the medium alone had no effect. These data suggest that NE induces LH release from the pituitary both by increasing LH-RH release from the MBH and by its direct action on the pituitary.

• 社団法人 日本内分泌学会の論文

著者

• Aono Toshihiro

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

• Sakumoto Tetsuro

  Department Of Neuroanatomy Osaka Medical School

• MIYAKE AKIRA

  Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University

• Tasaka Keiichi

  Department Of Obstetrics And Gynecology Faculty Of Medicine Osaka University

• Kurachi Keiichi

  Department Of Obstetrics & Gynecology Osaka Medical School

• KAWAMURA YASUHIRO

  Department of Obstetrics and Gynecology, Osaka University Medical School

• Miyake Akira

  Department Of Bioscience And Biotechnology Faculty Of Engineering Okayama University

• KURACHI KEIICHI

  Department of Gynecology and Obstetrics, Osaka University, Medical School

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