Prediction of the Three Dimensional Structure of the DBD of Centromere Protein B (CENP-B) in Comparison with the Structures of Myb, LexA and DtxR DBDs.
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概要
- 論文の詳細を見る
The centromere protein B (CENP-B) recognises DNA of a particular nucleotide sequence. We have identified two repeating units in the DNA-binding domain (DBD) of CENP-B by examining its amino acid sequence closely. The sequences of the two units resemble not only each other but also the sequences of the DBDs of transcription factors, Myb, LexA and DtxR. Since all the above transcription factors have three α-helices in their DNA-binding units, it is likely that each unit of CENP-B is also composed of three α-helices. We discuss possible ways in which the two units of CENP-B are combined along the same DNA.
- 日本学士院の論文
著者
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SUZUKI Masashi
MRC Lab. of Mol. Biol.
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Okazaki Tuneko
Department Of Melecular Biology School Of Science Nagoya University
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Masumoto Hiroshi
Department Of Cardiovascular Surgery Okazaki Municipal Hospital
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MASUMOTO Hiroshi
Department of Molecular Biology, School of Science, Nagoya University
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