DNA Recognition by a .BETA.-sheet. (2) Stereochemical Basis of DNA Bending by the .BETA.-sheets of MetJ and Arc Repressors.:(2) Stereochemical Basis of DNA Bending by the β-sheets of MetJ and Arc Repressors
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The stereochemical basis of DNA bending by a β-sheet is discussed in the light of crystal structures of MetJ and Arc repressors. The β-sheets of MetJ and Arc repressors bend the six basepair binding sites in the DNA to different directions. The β-sheet of MetJ compresses the major groove and thereby bends the DNA locally around the major groove, while that of ArcR widens the major groove at the centre and bends the DNA locally around the minor groove. Whether the major groove is compressed or widened seems to be dependent on the overall shape of the β-sheet, particularly the size of residues in some positions on the β-sheet. To close or open the major groove a pyrimidine-purine step at the centre of the binding site rolls to opposite directions.
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