Putative Zinc-Binding Domain of Plant Transcription Factor, AOBP, is Related to DNA-Binding Domains of Steroid Hormone Receptors and GATA1.
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概要
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A possible Zn-binding structure of a plant transcription factor, AOBP, and its mode of DNA-binding are discussed in reference to crystal/solution structures of steroid hormone receptors and GATA1. The amino acid sequence of AOBP (aa36-aa78) has five Cys residues. Cys[aa42] and Cys[aa45] are positioned with the same spacing as those found in the loop region of the reference proteins, while Cys[aa67] and Cys[aa70] in the same spacing as the other two Cys residues in the recognition helix. These, and some other features of the AOBP sequence suggest that this part of the protein folds into a Zn-binding domain, which corresponds to half the DNA-binding domain of a steroid hormone receptor and thereby binds to the target DNA site through an α-helix. Similar sequences are found in several other plant proteins and the evolutionary relation of these proteins and steroid hormone receptors is discussed.
- 日本学士院の論文
著者
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Kisu Yasutomo
Faculty Of Applied Biological Science Hiroshima University:(present Address)faculty Of Science Hiros
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SUZUKI Masashi
MRC Lab. of Mol. Biol.
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Esaka Muneharu
Facul. Appl. Bio. Sci. Hiroshima Univ.
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KISU Yasutomo
Faculty of Applied Biological Science, Hiroshima University
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