Sigma Factors have Two DNA-binding Domains which Resemble DBDs of Histone H5, BirA, LexA and DtxR.
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概要
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Sigma factors introduce sequence-specificity to DNA recognition by eubacterial RNA polymerases. Two domains of the factors, domains 4 and 2, bind, respectively, to the -35 and -10 sites in the promoters. We compare the amino acid sequences of the two domains of the major sigma subfamily (the σ70 subfamily) with those of other DNA-binding proteins (i.e. BirA, histone H5, LexA, and DtxR) of which the 3D structures are known. It is concluded that each of the two sigma domains probably has three α-helices, and that the third α-helix binds to the DNA. Possible ways in which the two domains are combined along the same DNA and contact patterns between amino acid residues in the two domains and the DNA bases are discussed.
- 日本学士院の論文
著者
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SUZUKI Masashi
MRC Lab. of Mol. Biol.
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MAKINO Kozo
The Research Institute for Microbial Diseases, Osaka University
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