Prediction of the Three Dimensional Structure of the DNA-Binding Domain of the LysR Family.
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概要
- 論文の詳細を見る
A considerable number of prokaryotic transcription factors belong to the LysR family. By comparison with the amino acid sequence of the putative DNA-binding domain (DBD) of BirA, for which the crystal structure has been determined, we predict that the LysR DBD has three α -helices and three β-strands, and that the third α-helix binds to DNA. Contacts between DNA bases and amino acid residues in the predicted recognition helix are discussed in comparison with those found in crystal structures of DNA-transcription factor complexes.
- 日本学士院の論文
著者
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SUZUKI Masashi
MRC Lab. of Mol. Biol.
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SUZUKI Masashi
MRC Laboratory of Molecular Biology
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NITTA Yoshinori
Department of Chemistry, Faculty of Science, Hokkaido University
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