Dopaminergic neurotoxins, MPTP and MPP+, inhibit activity of mitochondrial NADH-ubiquinone oxidoreductase.
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概要
- 論文の詳細を見る
Effects of MPTP and MPP+, potent dopaminergic neurotoxins, on the activity of NADH-ubiquinone oxidoreductase were studied using isolated mitochondrial preparation from C57BL/6J mouse brains. Both MPTP and MPP+ dose-dependently inhibited activity of NADH-ubiquinone oxidoreductase, however, MPTP found to be a more potent inhibitor compared with MPP+. Significance of these findings was discussed with regard to the mechanism of MPTP-induced neuronal degeneration.
- 日本学士院の論文
著者
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Saitoh Tomohiko
Department Of Applied Physics Tokyo University Of Science
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Mizuno Yoshikuni
Department Of Neurology Juntendo University School Of Medicine
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Sone Nobuhito
Department Of Biochemical Engineering And Science Faculty Of Computer Science And System Engineering
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SAITOH Tomohiko
Department of Neurology, Jichi Medical School
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