Piroheptine prevents loss of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced striatal loss of dopamine in mice.
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概要
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Effect of piroheptine, an anticholinergic agent having a dopamine- uptake inhibiting property, on MPTP-induced striatal loss of dopamine was studied in C57BL/6J mice. Pre-treatment with piroheptine almost completely prevented loss of Striatal dopamine in MPTP-injected mice. Piroheptine is another agent which prevents MPTP neurotoxicity.
- 日本学士院の論文
著者
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Saitoh Tomohiko
Department Of Applied Physics Tokyo University Of Science
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Mizuno Yoshikuni
Department Of Neurology Juntendo University School Of Medicine
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