Positive Associations between Dopamine D4 Receptor Polymorphism and Schizophrenia. A Study on Two Schizophrenic Groups with Genetic Loading and Unloading.:A Study on Two Schizophrenic Groups with Genetic Loading and Unloading

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概要

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• We studied the allelic distributions of 48-base pair repeat polymorphism of the dopamine D4 receptor (DRD4) gene in two groups of schizophrenic patients, one with any schizophrenic member in the family (L(+) group) and the other without schizophrenic family histories (L(-) group), and healthy controls. The frequency of the sum of the alleles of 4, 5, and 6 repeats in the L(+) group was significantly higher than the controls. The frequency of the allele of 4 repeats in the L(-) group was significantly higher than the controls. These results show positive allelic associations between DRD4 polymorphism and each of the two groups of schizophrenic patients.

• 日本学士院の論文

著者

• Nakamura Michiko

  Department Of Mathematics Faculty Of Science Science University Of Tokyo

• Hemmi Hiromichi

  Department Of Bacteriology Tohoku University School Of Medicine

• Suzuki Jiro

  Department Fo Newrosurgery:institute Of Neurological Disease Tohoku University

• Inoue Akira

  Department of Applied Chemistry, Faculty of Engineering, Toyo University:Bio-Nano Electronics Research Center, Toyo University

• INOUE Akira

  Department of Molecular Biology, Toho University School of Medicine

• Nakamura Michiko

  Department of Chemistry, Faculty of Science, Kobe University

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