SELECTIVE INHIBITION OF NUCLEOSIDE TRANSPORT INTO MOUSE LYMPHOMA L-5178Y CELLS BY CIMICIFUGOSIDE

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概要

• 論文の詳細を見る

• Cimicifugoside, a triterpenoid from Cimicifuga simplex, is a potent inhibitor of thymidine-^3H uptake by Raji cells, L-cells cl 1D cells, HeLa S3 cells and L-5178Y cells without affecting the growth rate of any cell type tested. It has also inhibited the uptake of purine and pyrimidine ribosides and deoxyribosides of adenosine, inosine, uridine and nucleoside analogs in L-5178Y cells. It did not inhibit phosphorylation of thymidine or adenosine, or the transport of nucleic acid bases, sugars, amino acids and arabinosyl analogs of nucleosides. The results suggest that cimicifugoside is a potent and selective inhibitor of nucleoside tranport at the plasma membrane site of mammalian cells.

• 公益社団法人日本薬学会の論文

著者

• HEMMI Hiromichi

  Department of Molecular Biology, Toho University School of Medicines

• Ishida Nakao

  Department Of Bacteriology Tohoku University School Of Medicine

• Kusano Genjiro

  Pharmaceutical Institute Tohoku University

• Hemmi Hiromichi

  Department Of Bacteriology Tohoku University School Of Medicine

• ISHIDA NAKAO

  Department of Bacteriology, Tohoku University School of Medicine

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