STRUCTURE-ACTIVITY RELATIONSHIPS FOR THE INHIBITION OF FORMATION OF ACID-FASTNESS IN MYCOBACTERIAL ORGANISMS BY COUMARINS AND CINNAMATES

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概要

• 論文の詳細を見る

• The relationships between the structure and inhibitory activity against the formation of acid-fastness in mycobacterial organisms were investigated in naturally occurring or synthetic coumarins and cinnamates. The presence of an OH-group at C_7 in the coumarin nucleus proved to be essential for the inhibitory activity. Likewise, the presence of a para-OH-group in cinnamates is also essential. Reduction of a conjugated α, β-double bond in both series resulted in a decrease of the ininhibitory activity. Shortening of the side chain of cinnamates resulted in total loss of the activity. The grouping 〓〓CO_2R appeared to be necessary for retaining the inhibitory activity.

• 公益社団法人日本薬学会の論文

著者

• Kusano Genjiro

  Pharmaceutical Institute Tohoku University

• Toida Tomohiro

  Pharmaceutical Institute Tohoku University

• KONDO Yoshikazu

  Pharmaceutical Institute, Tohoku University

• Kondo Yoshikazu

  Pharmaceutical Institute Tohoku University

• IMAI JIRO

  Pharmaceutical Institute, Tohoku University

• Imai Jiro

  Pharmaceutical Institute Tohoku University

• KUSANO GENJIRO

  Pharmaceutical Institute, Tohoku University

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