THE IMMUNE RESPONSE OF SPLENIC LYMPHOCYTES AFTER CIMICIFUGOSIDE TREATMENT IN VITRO AND PRETREATMENT IN VIVO
スポンサーリンク
概要
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Pretreatment of mouse splenocytes with Shigella lipopolysaccharide and concanavalin A followed by 50 ng/ml of cimicifugoside resulted in a 69% and 31% inhibition of blastogenesis compared to controls. The plaque forming colony assay using sheep erythrocytes (SRBC) showed a decreased number of plaque forming colonies after exposure of the splenic cells to 1 μg/ml of cimicifugoside. Cimicifugoside, 0.1 mg/mouse i. p. suppressed the anti-SRBC response in the plaque forming assay. The major inhibition of the antibody response occurred when cimicifugoside was administered 1 day before the primary immunization with SRBC. The delayed type hypersensitivity to picryl chloride was suppressed after i. v. administration of cimicifugoside, 1.0-2.0 mg/mouse. The immunosuppressive activity of cimicifugoside is preferentially directed toward B-cell function with larger doses being required for suppression of T-cell function.
- 公益社団法人日本薬学会の論文
著者
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HEMMI Hiromichi
Department of Molecular Biology, Toho University School of Medicines
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Ishida Nakao
Department Of Bacteriology Tohoku University School Of Medicine
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Hemmi Hiromichi
Department Of Bacteriology Tohoku University School Of Medicine
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HEMMI HIROMICHI
Department of Bacteriology, Tohoku University School of Medicine
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