Bromocriptine-induced Morphological Changes in Cultured Growth Hormone-producing Pituitary Adenoma Cells
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概要
- 論文の詳細を見る
Tumor tissues obtained from two patients with growth hormone-producing pituitary adenomas were cultured and treated with bromocriptine,then examined for morphological changes.Untreated tumor cells(controls)were morphologically well preserved and in terms of growth hormone secretion.Tumor cells exposed to bromocriptine for 7 days contained many vacuoles,which,after 14 days of exposure,grew larger and more numerous.These vacuoles appeared to be extensions of endoplasmic reticulum:some were connected to rough or smooth endoplasmic reticulum or,occasionally,to Golgi apparatus,and there were ribosomes on their surfaces.Bromocriptine apparently has cytocidal effects on growth hormone-producing pituitary adenoma in vitro.
- 日本脳神経外科学会の論文
- 1989-01-15
著者
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INOUE Akira
Department of Marine Bioresources Chemistry, Faculty of Fisheries, Hokkaido University
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NAKAI Osamu
Department of Orthopedic Surgery, Kudanzaka Hospital
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Nakai Osamu
Department Of Neurosurgery Brain Research Institute Niigata University
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Nakai Osamu
Department Of Surgical Neurology Yamagata University School Of Medicine
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Inoue Akira
Department Of Marine Bioresources Chemistry Faculty Of Fisheries Hokkaido University
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SAITO Shinjirou
Department of Surgical Neurology,Yamagata University School of Medicine
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KITAMURA Hirofumi
Department of Surgical Neurology,Yamagata University School of Medicine
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Saito Shinjirou
Department Of Surgical Neurology Yamagata University School Of Medicine
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Kitamura Hirofumi
Department Of Surgical Neurology Yamagata University School Of Medicine
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Inoue Akira
Department Of Surgical Neurology Yamagata University School Of Medicine
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Inoue Akira
Department Of Biochemistry Osaka City University Medical School
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Inoue Akira
Department of Applied Chemistry, Faculty of Engineering, Toyo University:Bio-Nano Electronics Research Center, Toyo University
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