Clinicopathologic Study of Perineural Invasion in Rectal Cancer
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概要
- 論文の詳細を見る
Perineural invasion (PNI) in rectal cancer was studied, prospectively.One-hundred patients (20%) were identified as having tumors with PNI. The incidence of PNI was significantly increased in tumors with moderate or marked venous invasion (30%, 64%), with moderate or marked lym-phatic permeation (37%, 72%), with liver metastasis (50%) and with peritoneal dissemination (64%). In cases of curative surgery, the incidence of PNI was significantly increased in MAC stage C2m+g or C3 (28%, 35%). There was no significant difference in the recurrence or survival rates between the patients with PNI and without PNI in MAC stage B2m+g. How-ever, there was a significant increase in local recurrence in the patients with both PNI and lymph node metastasis (p<0.05). Also, the patients with PNI in MAC stage C2m+g had a significantly lower 8-year survival rate (29.1%, p<0.001) . Multivariate analysis using Cox regression models demonstrated that PNI was an independent prognostic factor for survival.
著者
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Araki Yasumi
Department Of Surgery Kurume University Medical Center
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Akagi Yoshito
Department Of Surgery Kurume University School Of Medicine
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Shirouzu Kazuo
Department Of Surgery Kurume University
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Sasatomi Teruo
Department Of Surgery Kurume University School Of Medicine
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MORODOMI TATSUHISA
Department of Surgery, Kurume University School of Medicine
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KAKEGAWA TERUO
Department o f Surgery, Kurume University School of Medicine
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HOSHIKO MASARU
Departments of Surgery Fukuoka Prefectural Yanagawa Hospital
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ISOMOTO IROHARU
Department of Surgery, Kurume University School of Medicine
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