The Expression of p53, p21 and TGF .BETA.1 in Gastric Carcinoma
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概要
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The aim of the present study was to examine the significance of the p21 expression in gastric cancer. We examined the expression of p53, p21, TGF β1 and PCNA in 75 cases of gastric cancer using immunohistochemical examinations and the expression of p21 RNA by in situ hybridization (ISH). The combination of p53 and p21 expressions was related to depth of invasion, lymph node metastasis, and stage grouping. The survival curves of the p53 negative-Group and the p21-positive Group were significantly higher than those of the p53-positive and the p21-negative Group, the p53-and-p21-both-positive Group, and the p53-and-p21-both-negative Group (each p<0.01). The average PCNA Labelling Index (LI) of the p53-negative-and-p21-positive Group was significantly lower than that of either the p53-positive-and-p21-negative Group or the p53-and-p21-both-positive Group or the p53-and-p21-both-negative Group (p<0.01, p<0.05, p<0.05, respectively). All of the p53-and-p21-both-positive cases were TGF 61 positive, and the rate of the TGF β1 positive cases in the p53-and-p21-both-positive Group was significantly higher than that of the p53-positive-and-p21-negative Group, and than the rate in the p53-and-p21-both-negative Group (each p<0.01). The survival curves of the cases with expression of p21 RNA were higher than that of cases without p21 RNA (p<0.05). Many of the p53-positive-and-p21-negative cases were advanced cancer with very poor prognosis, but many of the p53-negative-and-p21-positive cases were early cancer with good prognosis. These results suggest that p21 suppressed synthesis of DNA via PCNA, and TGF β1 is a regulation factor for the expression of p21, and that the combination of p53 and p21 expression is concluded to be a useful prognostic marker of gastric carcinoma.
著者
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Shirouzu Kazuo
Department Of Surgery Kurume University
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Miyagi Motoshi
Department Of Surgery Kurume University School Of Medicine
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TAKEDA JINRYO
Department of Surgery, Kurume University School of Medicine
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MURAKAMI NAOTAKA
Department of Surgery, Kurume University School of Medicine
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KOGA ATSUHIKO
Department of Surgery, Kurume University School of Medicine
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YANO SHOJIRO
Department of Gastroenterology and Surgery, Kurume University School of Medicine
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AOYAGI KEISHIRO
Department of Gastroenterology and Surgery, Kurume University School of Medicine
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KOUFUJI KIKUO
Department o f Surgery, Kurume University School of Medicine
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TAKEDA JINRYO
Department o f Surgery, Kurume University School of Medicine
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SHIROUZU KAZUO
Department of Gastroenterology and Surgery, Kurume University School of Medicine
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