Morphological Change in the MNNG-Treated Rat Gastric Mucosa.
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概要
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To investigate the process of carcinogenesis in gastric cancer, we studied the histological features of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-treated rats . Samples of the gastric mucosa from both MNNG-treated and control rats were histologically examined every 2 months, for 10 months. In 40% of the MNNG-treated rats, atrophy in the gastric mucosa was observed after 2 months, and regenerative epithelium was observed after 4 months, followed by adenomatous proliferation and disappearance of the tight junction electron microscopically after 6 months. A small intestinal cancer had developed in 2 rats at 6 months. While gastric cancer had developed in 3 rats at 8 months, and in one of these 3 rats, peritoneal dissemination was observed macroscopically and histologically. These results suggested that adenomatous proliferation and disappearance of the tight junction observed electron microscopically were characteristic pathological features of precancerous lesions in the stomach in MNNG-treated rat.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Shirouzu Kazuo
Department Of Surgery Kurume University
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Tanaka Masaharu
Department Of Neuropsychiatry Mishima Hospital
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Aoyagi Keishiro
Department Of Surgery Kurume University School Of Medicine
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Terasaki Yasuhiro
Department Of Pathology Nippon Medical School Tokyo And Brain Science Institute Riken
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TAKEDA JINRYO
Department of Surgery, Kurume University School of Medicine
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YANO SHOJIRO
Department of Surgery, Kurume University School of Medicine
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MURAKAMI NAOTAKA
Department of Surgery, Kurume University School of Medicine
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KOHFUJI KIKUO
Department of Surgery, Kurume University School of Medicine
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HORI HARUKO
Department of Surgery, Kurume University School of Medicine
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YANO SHOJIRO
Department of Gastroenterology and Surgery, Kurume University School of Medicine
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AOYAGI KEISHIRO
Department of Gastroenterology and Surgery, Kurume University School of Medicine
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