Mast Cells and Histamine Release in Crohn's Disease.
スポンサーリンク
概要
- 論文の詳細を見る
To study the role of intestinal mast cells in Crohn's disease, a sensitive glass-fiber histamine assay was conducted in conjunction with mechanical dispersion of surgical specimens of 80 macroscopically actively inflamed colons, 40 non-inflamed colons, 40 actively inflamed ileums, and 16 non-inflamed ileums from patients with Crohn's disease and 96 control subjects. A strong correlation was found between the number of mast cells and the total histamine content in the controls (r=0.682) (p<0.05). The number of mast cells was decreased in Crohn's disease as compared with the controls (p<0.01). Intestinal mast cells release histamine in a dose-dependent manner after challenges with anti-IgE (1.875-240.0 U/ml). A significant difference was noted in the release by anti-IgE between actively inflamed and non-inflamed colons of patients with Crohn's disease or control subjects (p<0.01). Mast cells in actively inflamed tissue with Crohn's disease were shown to have different roles in the pathogenesis of inflammation.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Araki Yasumi
Department Of Surgery Kurume University Medical Center
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KAKEGAWA TERUO
Department of Surgery Kurume University School of Medicine
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STADIL FLEMMING
Department of Gastrointestinal Surgery, Rigshospitalet, Copenhagen, Denmark
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KAKEGAWA TERUO
Department o f Surgery, Kurume University School of Medicine
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