Monoclonal Antibody KOLT-2 Enhances DNA Synthesis and Expression of IL-2 Receptors on Activated T Cells.
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概要
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The functional properties of the KOLT-2 antigen, which was placed among the CD28 group in the 3rd International Workshop on Human Leukocyte Differentiation Antigens, are described. The method of production and a detailed characterization of the monoclonal antibody KOLT-2 including stain affinities and influence of T cell activation are presented. While KOLT-2 antigen was selectively expressed on human thymocytes, adult T-cell leuke-mia-lymphoma cells and activated T cells, the antigen was also spontaneously expressed by resting T cells after 24 hrs culture. Expression was transient, since it disappeared after 96 hrs. DNA synthesis and expression of Tac antigen on activated T cells was enhanced by stimulation with the KOLT-2. These observations suggest that the KOLT-2 antigen may have an important role in the early stages of T cell activation.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Hachisuka Hiroshi
Department Of Dermatology And 2nd Department Of Pathology Kurume University
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Karashima Tadashi
Department Of Dermatology Kurume University School Of Medicine
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Sasai Yoichiro
Department Of Dermatology And 2nd Department Of Pathology Kurume University
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OKUBO KEIJI
Department of Dermatology, Kurume University School of Medicine
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