Low Concentrations of Interferon-gamma Stimulate DNA Synthesis in Normal Human Keratinocytes during the Initial Stages of Cultivation.
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概要
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High concentrations of interferons can inhibit keratinocyte proliferation and induce the expression of HLA-DR antigen on keratinocytes. In the present study, the effects of low concentrations of recombinant human interferon α, β and γ were examined on DNA synthesis and the expression of HLA-DR and bullous pemphigoid (BP) antigens in normal human keratinocytes. Low concentrations of interferons induced DNA synthesis in normal human keratinocytes when epidermal cell growth factor and low Ca<SUP>++</SUP> were used during the initial stages of culturing. This result indicates that physiological concentrations of interferons can induce keratinocyte activation.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Hachisuka Hiroshi
Department Of Dermatology And 2nd Department Of Pathology Kurume University
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Karashima Tadashi
Department Of Dermatology Kurume University School Of Medicine
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Sasai Yoichiro
Department Of Dermatology And 2nd Department Of Pathology Kurume University
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Okubo Keiji
Department Of Immunology And The Third Department Of Internal Medicine Kurume University School Of M
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