肝細胞膜表面 asialoglycoprotein receptor 結合性標識合成糖タンパクによる肝機能予備力, 診断能の評価

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Asialoglycoprotein receptor (ASGPR) resides at the cell surface of hepatocytes, where it recognizes and binds galactose-terminated glycoproteins. After binding, the ligand-receptor complex is transported to hepatic lysozomes where the ligand is catabolized. Alteration of ASGPR binding has been demonstrated in various pathologic conditions of the liver. Tc-99m-Galactosyl-Neoglycoalbumin (Tc-99m-NGA) is a newly developed analog ligand of galactose-terminated glycoproteins. We evaluated clinical utility of Tc-99m-NGA in estimating hepatic functional reServe in 23 clinical cases. NGA Receptor Index, which is given by the radioactivity of the liver divided by that of the liver plus heart at 30 min after intravenous injection of Tc-99m-NGA, was decided to be a preliminary index of liver function provided by NGA studies in this report-Apositive correlation was observed between NGA Receptor Index and Cholinesterase, Hepaplastin test, Thrombotest, Prothrombin time and K-ICG. A negative correlation was observed between NGA Receptor Index and ICG R15 and Child- Turcotte Criteria Score. Analysis of the NGA dynamic curye is a promising method for the estimation of the heaptic functional reserve, as the dynamic curves correlate to the Asialogycoprotein receptor concentration.
社団法人日本肝臓学会の論文