ANTIVIRAL PROPERTIES OF p-ALKYLEPHEDRINE AND p-ALKYLNOREPHEDRINE

概要

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(1) The compounds of the hydrochlorides of p-alkylephedrine, and the hydrochlorides and methansulfonates of p-alkylnorephedrine were screened as to their chemotherapeutic effect. Among these compounds, Pseudo D. L.-p-methylnorephedrine methansulfonate named Methodrine was selected as the most effective.(2) Methodrine is effective in in vivo test, but not in in vitro test. This finding is of interest in consideration of mode of action of Methodrine.(3) Methodrine showed a comparatively low toxicity and pharmacological property suitable for clinical use.(4) Methodrine is more promising than PANS-610, in balance of effectiveness, toxicity and side action.(5) The therapeutic action of Methodrine may offer a key for the clarifing the mechanism of the multiplication of Jap-B virus, which is still in the dark.
The Keio Journal of Medicineの論文