ACCELERATING EFFECT OF ARGININE ON THE DEVELOPMENT OF CYTOPHATIC EFFECT OF ADENO VIRUS

概要

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In both of Hep. No. 2 and KB cells, arginine remarkably accelerated the development of the cytophatic effect of the type 2 strain of adeno virus. This effect, "Arginine Effect, " was observed in not only type 2 virus but other strains such as type 1, type 5 and type 6 strains of adeno virus. The acceleration of the lowering of pH of culture fluid of the cells infected with adeno virus in the arginine rich group was not found. The stimulation of arginine on the degree and the rate of the viral release from host cells also was not found. In the group riched with arginine, the clear increase of the intracellular multiplication of adeno virus was observed. Thus, it may be considered that the main mechanism of "Arginine Effect" should be in the multiplication-mechanism of adeno virus in intracellular site. This mechanism is not of the stimulation of the activity of Ornithine-cycle, but of some specific effect of arginine on the replication-mechanism of adeno virus particles.
The Keio Journal of Medicineの論文