ANTIVIRAL EFFECT OF GUANIDINE AND ITS DERIVATIVES:PART 1. THE INHIBITORY EFFECT OF GUANIDINE ON THE MULTIPLICATION OF POLIOMYELITIS VIRUS IN TISSUE CULTURE
スポンサーリンク
概要
- 論文の詳細を見る
The antiviral effect of Guanidine on poliomyelitis virus in HeLa cells was investigated. 10-3M of Guanidine exerted the remarkable inhibitory effect on the multiplication of all of type-1, type-2 and type-3 of poliomyelitis virus. The inhibitory effect of Guanidine should neither be due to the virus inactivating action nor be caused by the influence on the viral adsorption onto host cells. From the results presented in this paper, it should be emphasized that the action site of this compound should be in the intracellular viral multiplication, particularly in the reproduction stage of the multiple cycle of viral growth.
- The Keio Journal of Medicineの論文
著者
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Toyoshima Shigeshi
Pharmaceutical Institute Keio-gijuku University
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Ueda T.
Pharmaceutical Institute, School of Medicine, Keio University
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NOMOTO JUNKO
Pharmaceutical Institute, School of Medicine, Keio University
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SETO YOSHIKO
Pharmaceutical Institute, Keio University
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TSUJI TADAKAZU
Pharmaceutical Institute, School of Medicine, Keio University
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TSUJI TADAKAZU
Pharmaceutical Institute, School of Medicine Keio University
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