THE SYNTHESIS AND ANTIVIRAL ACTIVITY OF 1- (p-SUBSTITUTED PHENYL)-3-DIMETHYLAMINO-1-PROPANOL

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概要

• 論文の詳細を見る

• 1) Guanidine nitrate (G.N.) was found to inhibit the multiplication of the K-2211 strain of common cold virus. Based on this finding, the method of screening for the K-2211 strain virus was arranged.2) According to the above screening method, 1-(p-substituted phenyl)-3-dimethylamino-1-propanols were screened as to their antiviral activities for the K-2211 strain virus. 1-Biphenylyl-3-dimethylamino-l-propanol was found to possess the almost equal activity with that of G.N.3) The relationship between the antiviral properties and the chemical constitution of 1-(p-substituted phenyl)-3-dimethylamino-l-propanols was dis-cussed.

• The Keio Journal of Medicineの論文

著者

• Toyoshima Shigeshi

  Pharmaceutical Institute Keio-gijuku University

• Ueda Takeo

  Pharmaceutical Institute Keio-gijuku University

• TSUJI TADAKAZU

  Pharmaceutical Institute, School of Medicine, Keio University

関連論文

• Researches on Chemotherapeutic Drugs against Viruses. XIII. : The Relationship between Surface-Tension Lowering and Antiviral Activities of 3-Alkylphenylazo-4-amino-and 3-Alkylphenylazo-4-hydroxynaphthalenesulfonic Acid.
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• ANTIVIRAL EFFECT OF ALKYLPYRIMIDINE DERIVATIVES
• POTENTIATION OF AMINO ACID ANTAGONISTS ON ANTIVIRAL EFFECT OF GUANIDINE
• ACCELERATING EFFECT OF ARGININE ON THE DEVELOPMENT OF CYTOPHATIC EFFECT OF ADENO VIRUS
• THE ANTIVIRAL EFFECT OF GUANIDINE AND ITS DERIVATIVES:III. THE DEVELOPMENT OF GUANIDINE RESISTANT AND GUANIDINE DEPENDENT POLIO VIRUS IN TISSUE CULTURE
• FUNDAMENTAL CHEMOTHERAPEUTIC STUDIES AND CLINICAL EFFECT OF PANS AGAINST JAPANESE B ENCEPHALITIS
• ANTIVIRAL PROPERTIES OF p-ALKYLEPHEDRINE AND p-ALKYLNOREPHEDRINE
• THE ANTIVIRAL EFFECT OF GUANIDINE AND ITS DERIVATIVES:V. ANTIVIRAL EFFECT OF ISONICOTINYLGUANIDINE AND NIOOTINYLGUANIDINE
• THE SYNTHESIS AND ANTIVIRAL ACTIVITY OF 1- (p-SUBSTITUTED PHENYL)-3-DIMETHYLAMINO-1-PROPANOL
• ANTIVIRAL EFFECT OF GUANIDINE AND ITS DERIVATIVES:PART 1. THE INHIBITORY EFFECT OF GUANIDINE ON THE MULTIPLICATION OF POLIOMYELITIS VIRUS IN TISSUE CULTURE
• THE EFFECT OF ALKYLBENZENESULFONAMIDE ON LANSING STRAIN VIRUS IN MICE

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