FUNDAMENTAL CHEMOTHERAPEUTIC STUDIES AND CLINICAL EFFECT OF PANS AGAINST JAPANESE B ENCEPHALITIS

概要

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The fundamental experiments can be summarized as follows. PANS acts directly on Japanese B encephalitis virus, both unpurified and purified, and exerts a strong inactivating effect. A significant therapeutic effect is observed by a single intravenous injection of PANS 72 hours after intracerebral, intranasal or intraperitoneal inoculation of the virus. Examination of the time of effect from the standpoint of virus proliferation shows that PANS is effective even after virus has multiplied in the brain. A therapeutic effect can therefore be anticipated in Japanese B encephalitis patients.Examination of the acute toxicity, effect on respiration, blood pressure, electrocardiogram, excised heart, intestine in vivo and excised intestine shows that PANS possesses no detrimental action on the internal organs and gives rise to no marked side effect. The drop in PANS blood concentration is rapid and in view of the fact that a maximum concentration is seen in the brain in 6 hours, it would be necessary to give PANS at frequent intervals when it is to be used clinically. It is suggested from the rapid excretion in the urine that there is little danger of accumulation.On the basis of these findings, PANS was tried clinically for the treatment of Japanese B encephalitis in the summer of 1955.
The Keio Journal of Medicineの論文