Transition from chronic hepatitis to liver cancer in long survived long evans cinnamon(LEC) rats with spontaneous hepatitis.

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We investigate, with urinary, hematological, biological, immunological and histopathological examinations, the process from chronic liver disease to spontaneous liver cancers in long survived LEC rats in comparison with age-matched Long Evans Agouti (LEA) rats. We then got the following results.<BR>LEC rats had the high frequent incidence of anemia, abnormal renal function and immuno-suppressive status. As for liver funciton, clinicobiochemical data showed the chronic liver dysfunction type and histopathology showed the figure of chronic hepatitis with both spotty necrotic and small regenerating hepatocytes.<BR>Oval cells, hyperplastic foci and hyperplastic nodules were detected in the process of spontaneous hepatocarcinogenesis in LEC rats and all the LEC rats eighteen months after birth had liver cancers. From these ruslts, we speculated that the long survived LEC rats, regardless of whether acute hepatitis or not, suffered from continuous liver damage and chronic hepatitis, were worsened progressively and resulted in liver cancers.