神経芽腫剖検例の検討 : James 療法例と CPM 大量療法例の比較

概要

論文の詳細を見る
In spite of improvement in the treatment modality, the survival rate of the patients with the advanced neuroblastoma remains poor. The result of clinicopathological study in 14 autopsied children who had been treated by either James' therapy or high-dose CPM therapy for advanced neuroblastomawere presented. 1. Seven children treated by James' therapy died of progression of the primary tumor,or bleeding tendency due to the side effect of the chemotherapy. 2. The remaining 7 children treatedby high-dose CPM therapy died of dyspnea caused by bloody pleural effusion and compression by the enlarged liver, or bleeding from the liver metastasis. 3. There was no significant difference of thesite or number of the metastasized organs between two groups. 4. High-dose CPM therapy was effective for the primary tumor, but ineffective for control of bone, lymph nodes, and liver metastasis. An effective therapy for the control of metastasis in the bone, lymph nodes and liver would be necessary to improve the results of the treatment of the advanced neuroblastorna.
日本小児外科学会の論文
1983-06-20