進行性神経芽腫に対する術前エンドキサン大量療法

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In spite of improvement of the outcome of the management in neuroblastoma and rhabdomyosarcoma, survival in patients with advanced neuroblastoma has remained unchanged. Accordingly, a treatment with high dose cyclophosphamide (CPM) was carried out in these patients before the operation. Then their operability and outcome were studied. Materials and Methods: CPM 40-100 mg/kg was preoperatively administered for ten patients with advanced neuroblastoma treated in our clinic during the past 2 years. The ages were from 10 months to 13 years old. There were 3 primary sites in the adrenal and 5 in the retroperitoneum. CPM was administered for 12 hours in one or two successive days. The operation was performed 3-4 weeks after this treatment. The same treatment with CPM was continued postoperatively. Results: The general condition of patients was markedly improved after a few days. The huge tumor decreased in size after one week in all cases, and was resected almost completely except for one patient. Pleural effusion seen in 2 patients, hemiplegia in one, and orbital echymosis in 5 before CPM treatment, disappeared completely. Toxicities of CPM treatment were leucopenia in 8 patients, alopecia in 9, and hematuria in one. They were all controlled well. Seven out of 10 patients are still arive for 4 to 14 months after operation. Three patients died 8, 9 and 10 months after operation. Mean survival time prolonged over 5 month in deceased patients. High dose CPM treatment is a useful preoperative chemotherapy for patients with advanced neuroblastoma.
日本小児外科学会の論文
1980-04-20

進行性神経芽腫に対する術前エンドキサン大量療法

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