肝癌および切除後再発診断における血清TNF-α,GN-CSFの有用性

概要

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TNF-α, IL-1β, IL-2, IL-6, GM-CSF in serum of patients with HCC were measured before and after operation. We made a comparison between these cytokines with recurrence and without recurrence and investigated whether these cytokines are useful tumor markers of not. Serum levels of TFN-α, IL-1β, IL-2, IL-6, GM-CSF were high in patients with HCC before operation in comparison with those of normal controls. The levels of TNF-α, IL-1β, GM-CSF in patients without recurrence decreased and IL-6 increased. The levels of TNF-α, IL-1β, GM-CSF in patients with recurrence increased again. The levels of TNF-α and GM-CSF in cancer tissue were high, the levels of IL-2 and IL-6 in non-cancer tissue were high.<BR>The levels of TNF-α, IL-6 and GM-CSF in supernatant of five HCC cell lines were high. These results suggest that TNF-α and GM-CSF in serum are important on diagnosis of HCC and recurrence after operation.
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