Antibiotic susceptibility of treponema hyodysenteriae and its metabolic and physiological specificity: A simple test system for cytotoxicities of various drugs.
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Susceptibility of Treponema hyodysenteriae to various antibiotics and metabolic inhibitors was examined in comparison to those of various bacteria and fungi. As for susceptibility to DNA synthesis inhibitors, this treponema was sensitive not to furazolidone but to ethidium bromide and chloroquine. This treponema was resistant to rifampicin and actionmycin D; RNA synthesis inhibitors but sensitive to most of the protein synthesis inhibitors for procaryotes and inhibitors for oxidative phosphorylaton and electron transport systems, such as gramicidine S, azid and antimycin. This treponema was also a little resistant to colistin and ampicillin but very sensitive to clotrimazole. These results suggested that this organism have procaryotic ribosome system but eucaryotic membrane and electron transport systems. Therefore, we could use this organism as an agar plate-culturable indicator strain of eucaryotic membrane system to test the cytotoxicity of the newly developed antibacterial and other drugs.
- The Keio Journal of Medicineの論文
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