大腸mucusreleaseに関する研究 (第一報) I. 正常大腸

概要

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The release of goblet cell mucus (GCM) was examined in immune reaction-system of colonic mucosa of normal rats (SD rats). Though there are several studies as for mucus release of small intestine, no papers reporting colonic GCM release are found. Lake A.M. et al. previously reported that in the immune reaction of small intestine of normal rats, the discharge of GCM increased after intraduodenal challenge of specific antigen in the orally immunized animals. We examined release of colonic GCM in antigen-antibody system in rats, who received intrarectal instillation (challenge) of several test-antigens after repeated immunization of single BSA antigen through rectal mucosa. Intrarectal infusion of BSA into immunized rats with BSA produced no greater GCM release than the GCM release obserbed on challenge with buffer alone (control) or other antigen (OVA), comparing with the results in case of small intestine by Lake A.M. et al. These results suggest that there was difference in local antigen-antibody reaction on the surface of normal mucosa between small intestine and colon.
日本臨床免疫学会の論文