The effects of vitamin B6 on immune system

概要

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Much interest has been shown in the relationship between vitamins and immunity sincemany reports on thymus atrophy in vitamin B6 deficient animals, suggesting that vitamins greatly influence immunity, were published. We examined the immune system of vitamin B6 deficient guinea pigs (VB6 DG) and performed the recovery test by giving vitamin B6 to clarify the action of vitamin B6 on the immune system. We also investigated the influences of vitamin B6 and anti-vitamin B6 on the blast-transformated reaction of peripheral lymphocytes simulated with PHA. Atrophy was noted around the T cell-abundant region of thymus and peripheral lymphocyte count was decreased to about 25% of the control. The number of T cells was decreased remarkably. ADCC% and gamma-globulin in VB6 DG were also reduced to one half of the control, but were recovered by vitamin B6 to 80 to 90% of the control. The peripheral lymphocyte blast-transformation rate in guinea pigs was lowered by anti-vitamin B6. We suggest that vitamin B6 influences the immune system by acting on the thymus and peripheral lymphocytes simultaneously.
日本臨床免疫学会の論文