Marked Species-Difference in the Vascular Angiotensin II-Forming Pathways: Humans versus Rodents.
スポンサーリンク
概要
- 論文の詳細を見る
Using isolated arteries, we demonstrated a marked difference in the angiotensin II-forming systems between human and rodent vessels. In human arteries, only 30-40% of the conversion of angiotensin I to angiotensin II depended on the angiotensin-converting enzyme (ACE), and the rest of the angiotensin II formation was ascribed to chymostatin-sensitive angiotensin II-generating enzyme (CAGE). On the contrary, angiotensin II formation in rodent arteries totally depended upon ACE, without any sign of CAGE involvement. Such a marked species-difference can be relevant to the reported difference between humans and rodents in the ACE inhibitor effects on the myointimal hyperplasia after intimal balloon injury.
- 公益社団法人 日本薬理学会の論文
著者
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SHIOTA Naotaka
Department of Pharmacology, Osaka Medical College
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Song Keifu
Department Of Pharmacology Osaka Medical Colleg
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Shiota Naotaka
Department Of Pharmacology Osaka Medical Colleg
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Oka Yuko
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Okunishi Hideki
Department Of Pharmacology Shiga University Of Medical Sciences
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Miyazaki Mizuo
Department Of Pharmacoldgy Osaka Medical College
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Kawamoto Tatsuhiko
Department of Pharmacology, Osaka Medical College
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