Indirect and direct suppressive actions of morphine on dorsal horn neurons in rabbits.
スポンサーリンク
概要
- 論文の詳細を見る
The analgesic mechanism of morphine on the spinal nociceptive transmission was compared in rabbits with the intact and cold-blocked states of the spinal cord. The degree of the suppressive effect of morphine (2 mg/kg) on the bradykinin-induced activity was significantly greater in the intact than in the coldblocked states. Morphine (4 mg/kg) suppressed the nociceptive responses to similar levels in both states. These results suggest that in a small dose, the indirect suppressive action is more important than the direct action. In a larger dose, the suppressive action is probably exerted primarily by the direct spinal action.
- 公益社団法人 日本薬理学会の論文
著者
-
Okuda Takahiko
Department Of Anesthesiology Kinki University School Of Medicine
-
Suekane Keita
Department Of Anesthesiology Kinki University School Of Medicine
-
Miyamoto Kazuyuki
Department Of Anesthesiology Kinki University School Of Medicine
-
OKUDA Takahiko
Department of Anesthesiology, Kinki University School of Medicine
関連論文
- Anesthetic management in coronary artery bypass grafting
- A case of allergic reaction to antibiotics during anesthesia
- Anesthetic management for the minimally invasive Nuss procedure in 21 patients with pectus excavatum
- Management of postoperative pain with propofol and epidural morphine after esophagectomy
- Anesthesia for laparoscopic abdominal surgery in children
- A case of sinus arrest during general anesthesia with epidural anesthesia in surgical operation
- Evaluation of laser Doppler method for measurement of hepatic tissue blood flow
- Effects of acute re-expansion of unilateral collapsed lung on the lung water and the pulmonary circulation in dogs
- A 10 year review of anesthetic cases at Kinki University Hospital
- Involvement of Potassium Channels in Spinal Antinociceptions Induced by Fentanyl, Clonidine and Bethanechol in Rats
- Strain Differences to Effects of Aging on Concentrations of Amino Acids in Cerebrospinal Fluid between Sprague Dawley Rat and Wistar Kyoto Rat
- Enhancement of midazolam antinociceptive effect by diltiazem in spinal cord of rats
- Yohimbine and flumazenil : effect on nitrous oxide-induced suppression of dorsal horn neurons in cats
- Enhancement of Clonidine Antinociceptive Effect by Diltiazem in Spinal Cord of Rats
- L-arginine produces antinociceptive effects in spinal cord of rats
- Interaction of Clonidine and Midazolam in the Spinal Cord of the Rat
- Descriptive analysis of patients at the intensive care unit of Kinki University Hospital in the past eighteen years
- Continuous epidural infusion of morphine for postoperative analgesia after abdominal surgery
- The Differential Cardioprotective Effects of Nucleoside Transport Inhibitor on Moderate and Deep Hypothermic Ischemia with Cold Cardioplegia
- Risk factors for early postoperative hypoxemia in the recovery room
- Anesthesia for noncardiac surgery in patients with previous myocardial infarction
- Intracellular K^+ Activity Measurements with Liquid Ion-Exchanger K^+ Microelectrodes
- -0947- EFFECTS OF LAZAROID(U-74500A)ON LIPID PEROXIDATION AND CARDIAC FUNCTION AFTER REPERFUSION IN BLOOD PERFUSED RABBIT HEARTS(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- EFFECTS OF SUPEROXIDE DISMUTASE ON REDUCING REPERFUSION INJURY IN OPEN HEART SURGERY : A CLINICAL TRIAL OF RECOMBINANT HUMAN SOD
- Electrodeposition of Super Hard Ni-B/Diamond Composite Coatings
- Indirect and direct suppressive actions of morphine on dorsal horn neurons in rabbits.