Inhibitory effects of trifluoperazine and chlorpromazine, calmodulin inhibitor, on autoregulation of renal blood flow.
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概要
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An intra-arterial infusion of a calmodulin inhibitor trifluoperazine (3 mg/min) or chlorpromazine (5 mg/min) caused obvious inhibition of autoregulation of renal blood flow in dogs. Simultaneous infusion of CaCl<SUB>2</SUB> (30 mg/min) or Ca channel activator BAY K 8644 (5 μg/min) with these calmodulin inhibitors reduced renal blood flow, but could not block the inhibitory activity of calmodulin inhibitors on the autoregulation. The present experiment shows the contribution of the Ca-calmodulin system to the mechanism of autoregulation of renal blood flow.
- 公益社団法人 日本薬理学会の論文
著者
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Yokota Syunji
Department Of Pharmacology And Toxicology Hatano Research Institute
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Ogawa Nobuyuki
Department Of Fundamental Science Gifu National College Of Technology
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Ono Hiroshi
Department Of Agronomy Faculty Of Agriculture Tottori University
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OGAWA Nobuyuki
Department of Pharmacology and Toxicology, Hatano Research Institute, Food and Drug Safety Center
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