Influence of Bay K 8644 on aequorin-loaded human platelets.
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概要
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In aequorin-loaded human platelets, Bay k 8644 (1-100 μM) had no effect on the resting level of cytoplasmic Ca<SUP>2+</SUP> and did not induce aggregation by itself. Though the rise of cytoplasmic Ca<SUP>2+</SUP> and platelet aggregation induced by thrombin (0.1 U/ml) also was not inhibited by 1-10 μM of Bay k 8644, at concentration of 3-10 μM, it dose-dependently reduced those induced by collagen (5 μg/ml). The present study shows that human platelets do not have dihydropyridine sensitive Ca channels.
- 公益社団法人 日本薬理学会の論文
著者
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Ogawa Nobuyuki
Department Of Fundamental Science Gifu National College Of Technology
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Ono Hiroshi
Department Of Agronomy Faculty Of Agriculture Tottori University
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OGAWA Nobuyuki
Department of Pharmacology and Toxicology, Hatano Research Institute, Food and Drug Safety Center
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