Hypotensive Effect of a Phosphorus-Containing Novel Angiotensin Converting Enzyme Inhibitor, (S)-1-[6-Amino-2 [ [hydroxy (4-phenylbutyl) phosphinyl] oxy]-1-oxohexyl]-L-proline (SQ 29 852) in Conscious Hypertensive Dogs
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概要
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The hypotensive efficacy of (S)-1-[6-amino-2 [ [hydroxy (4-phenylbutyl) phosphinyl] oxy]-1-oxohexyl]-L-proline (SQ 29 852), a phosphorus-containing novel angiotensin converting enzyme inhibitor (ACEI) was examined in conscious two-kidney, one-clip Goldblatt hypertensive dogs. The acute hypotensive effect of SQ 29 852 was compared with that of captopril or enalapril at 3 mg/kg, p.o., for each, and the potencies were ranked as follows, enalapril > SQ 29 852 > captopril. On the other hand, the hypotension caused by repetitive dosing with SQ 29 852 (3 mg/kg, p.o./d for 7 d followed by another 7-d treatment with 10 mg/kg, p.o./d) was somewhat more marked than that by enalapril at the same dosage. Blood urea nitrogen (BUN) increased in all the animals given enalapril, while that in all of the SQ 29 852-treated animals did not increase. These results indicate that SQ 29 852 is a potent, and long-lasting ACEI with a possible low incidence of side effects.
- 公益社団法人日本薬学会の論文
著者
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Ohara N
Department Of Pharmacology And Toxicology Hatano Research Institute
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Ono H
Univ. Tokyo Tokyo Jpn
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Ogawa N
Department Of Pharmacology Ehime University School Of Medicine
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Yokota Syunji
First Laboratory Of Toxicology Hatano Research Institute Food And Drug Satety Center
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Yokota Syunji
Department Of Pharmacology And Toxicology Hatano Research Institute
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Ohara Naoki
Department Of Pharmacology And Toxicology Hatano Research Institute
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Ogawa Nobuyuki
Department Of Fundamental Science Gifu National College Of Technology
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Ogawa N
Department Of Fundamental Science Gifu National College Of Technology
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Ono Hiroshi
Department Of Agronomy Faculty Of Agriculture Tottori University
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TAKIZAWA Mihoko
Department of Pharmacology and Toxicology, Hatano Research Institute
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KATSUMURA Hideo
Department of Pharmacology and Toxicology, Hatano Research Institute
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Katsumura Hideo
Department Of Pharmacology And Toxicology Hatano Research Institute
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Takizawa Mihoko
Department Of Pharmacology And Toxicology Hatano Research Institute
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