Tracheal instillation of diesel exhaust particles component causes blood and pulmonary neutrophilia and enhances myocardial oxidative stress in mice
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概要
- 論文の詳細を見る
The influences of inhaling particulate air-pollutants on hematopoiesis and myocardial oxidative stress were investigated in mice by intratracheal instillation (IT) of diesel exhaust particles (DEP), its dichloromethane soluble-component (DMSC) or residual particle-component (RPC). After IT, time courses of cytokine levels in bronchial alveolar lavage fluid (BALF), peripheral blood cell count, myocardial myeloperoxidase (MPO) activity and myocardial chemokine levels were observed for 24hr. RPC caused sustained blood neutrophilia while that caused by DEP and DMSC was transient. RPC also caused sustained elevations of granulocyte colony-stimulating factor (G-CSF) and interleukin (IL)-6 levels in BALF. Furthermore, IL-1β level in BALF in the RPC group was significantly elevated at 24hr after IT. Significant positive correlations were observed between blood neutrophil count and IL-6/G-CSF levels in BALF. MPO activity in the myocardium was increased by RPC at 12 and 24hr after IT while the activities in the kidney and the liver were not affected. Significant correlation was also observed between myocardial MPO activity and blood neutrophil count at 12hr after IT, for all three substances. From these results, it was concluded that particle component of DEP may enhance myocardial oxidative stress via blood neutrophilia and the elevation of cytokine levels in BALF.
- 日本トキシコロジー学会の論文
- 2008-12-01
著者
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Kobayashi Hiroyuki
Department Of Pediatric Surgery Juntendo Univ
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Ohara Naoki
Hatano Res. Inst. Food And Drug Safety Center
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Ohara Naoki
Laboratory Of Pharmacology Hatano Research Institute Food And Drug Safety Center
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Ohara Naoki
Laboratory Of Pharmacology Hatano Research Institute Food And Drug Satety Center
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Hirabayashi Naoyuki
Laboratory Of Analytical Chemistry Hatano Research Institute Food And Drug Satety Center
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Tachibana Shigehiro
Laboratory Of Pharmacology Hatano Research Institute Food And Drug Satety Center
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Kobayashi Hiroyuki
Department Of Applied Chemistry Saitama University
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Yokota Syunji
First Laboratory Of Toxicology Hatano Research Institute Food And Drug Satety Center
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Yokota Syunji
Department Of Pharmacology And Toxicology Hatano Research Institute
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Seki Takayuki
2nd Laboratory Of Toxicology Hatano Research Institute Food And Drug Satety Center
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Ohara Naoki
Laboratory Of Applied Pharmacology Hatano Research Institute Food And Drugs Safety Center
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Nagata Tomoko
Laboratory Of Microbiology Hatano Research Institute Food And Drug Safety Center
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Naito Yukiko
Laboratory of Pharmacology, Hatano Research Institute, Food and Drug Satety Center
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Nakasaka Toshiaki
Laboratory of Microbiology, Hatano Research Institute, Food and Drug Safety Center
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Naito Yukiko
Laboratory Of Pharmacology Hatano Research Institute Food And Drug Satety Center
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Yokota Syunji
First Laboratory Of Toxicology Hatano Research Institute Food And Drug Safety Center
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Yokota Syunji
First Lab. Of Toxicology
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Kobayashi Hiroyuki
Department Of Anesthesiology Okayama Red Cross Hospital
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