Effects of acetyl-L-carnitine on the brain lipofuscin content and emotional behavior in aged rats.
スポンサーリンク
概要
- 論文の詳細を見る
The effects of long-term dosing with acetyl-L-carnitine (ALC) were examined in aged rats, and they were compared with those in young rats. ALC significantly reduced the lipofuscin deposition in the brain of aged rats. Emotional parameters such as locomotor activity and rearing behavior are lower in aged rats than in young rats, and these behaviors decreased in both age groups during the experiments. ALC diminished the decrease of these emotional behaviors, especially in rearing behavior in the aged rats. Furthermore, ALC had no effect on body weight gain. These results might reflect one of the main beneficial pharmacological mechanisms of ALC in clinical use.
著者
-
Ono Takaharu
Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
Anami Koretake
Research Laboratories Yoshitomi Pharmacoceutical Industries Ltd.
-
SATOH Hisashi
Research Laboratories, Fujisawa Pharmaceutical Co. Ltd.
-
Yasuda Hiroshi
Research Center For Advanced Science And Technology The University Of Tokyo
-
MATSUMOTO Masahiro
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
-
ANAMI Koretake
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
-
FUJII Toshiyuki
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
-
KUWAKI Tomoyuki
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
-
SHIRAKAWA Kiyoharu
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
-
KOHJIMOTO Yoshiro
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
-
OGAWA Toshikazu
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
-
YASUDA Hiroshi
Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd.
関連論文
- Live Imaging of Radiation-Induced Apoptosis by Yolk Injection of Acridine Orange in the Developing Optic Tectum of Medaka
- Correlation Between Mercury Concentrations in Hair and Dental Amalgam Fillings
- Reduced Exposure to Mercury in Patients Receiving Enteral Nutrition
- Identification of Human Drug-Metabolizing Enzymes Involved in the Metabolism of SNI-2011
- A MODEL FOR MISMATCH RESOLUTION OF WEB PAGES(International Workshop on Advanced Image Technology 2006)
- Thermal-Neutron Capture Cross Section and Resonance Integral of Americium-241
- Acquisition and Maintenance of Knowledge for Online Navigation Suggestions(Artificial Intelligence and Cognitive Science)
- A New Similarity Measure to Understand Visitor Behavior in a Web Site(Information Processing Technology for Web Utilization)
- Cross Section of Thermal-Neutron Capture Reaction by ^Tc
- A Spectrum Tree Kernel
- A STUDY ON FEATURE POINT INTERPOLATION FOR SURFACE SHAPE RECOGNITION(International Workshop on Advanced Image Technology 2006)
- Transparent Gaze Communications for Multiparty Videoconference System(Human Communication I)
- A study on trying virtual T-shirt on by using T-shirt pattern recognition (Computer Vision, Medical Applications and Networked MM)(International Workshop On Advanced Image Technology (IWAIT2004))
- A Proposal of the Model about "Yoi" Content Decision and its Application (Computer Vision, Medical Applications and Networked MM)(International Workshop On Advanced Image Technology (IWAIT2004))
- A-16-29 ALTERNATIVE IMAGE VIEWING FOR ISHINDENSHIN SYSTEM
- A Study on Gaze Communications and Synchronous Pointing of Multiparty Videoconference for IshinDenshin System
- A Study on Gaze Communications and Synchronous Pointing of Multiparty Videoconference for IshinDenshin System
- A Study on Gaze Communications and Synchronous Pointing of Multiparty Videoconference for IshinDenshin System
- Redox Equilibrium of U^/U^ in Molten NaCl-2CsCl by UV-Vis Spectrophotometry and Cyclic Voltammetry
- Study on Redox Equilibrium of UO_2^ /UO_2^+ in Molten NaCl-2CsCl by UV-Vis Spectrophotometry
- Protection of Negative Gravitaxis in Euglena gracilis Z against Gamma-ray Irradiation by Trolox C
- Association of Aging with Minerals in Male Japanese Adults
- ( ±) : cis : 2 : Methylspiro[1,3 : oxathiolane : 5,3' : quinuclidine] Hydrochloride, Hemihydrate (SNI : 2011, Cevimeline Hydrochloride) Induces Saliva and Tear Secretions in Rats and Mice: The Role of Muscarinic Acetylcholine Receptors
- Measurement of Neutron Capture Cross Section Ratios of ^Cm Resonances Using NNRI
- EFFECT OF SUFOXAZINE (Y-8894) ON LEARNING AND MEMORY IN ANIMALS
- In-situ Measurement of UO_2^ Concentration in Molten NaCl-2CsCl by Differential Pulse Voltammetry
- Synthesis and Structure-activity Relationships of 1β-Methylcarbapenems with Quaternary Ammonium Side Chains
- Synthesis and Structure-activity Relationships of a Novel Oral Carbapenem. CS-834
- Metallomics study using hair mineral analysis and multiple logistic regression analysis : relationship between cancer and minerals
- High Accumulation of Aluminum in Hairs of Infants and Children
- Relationship between Body Mass Index and Minerals in Male Japanese Adults (特集:骨と微量元素)
- Mineral Imbalance in Children with Autistic Disorders
- High Toxic Metal Levels in Scalp Hair of Infants and Children
- Measurement of Effective Capture Cross Section of Americium-243 for Thermal Neutrons
- Measurement of Effective Capture Cross Section of ^Np for Thermal Neutrurons
- Measurement of Thermal Neutron Capture Cross Section and Resonance Integral of the ^Np(n, γ)^Np Reaction
- Measurement of Thermal Neutron Capture Cross Section and Resonance Integral of the ^Ho(n,γ)^Ho Reaction using a Two-Step Irradiation Technique
- Precise Measurement of Gamma-ray Emission Probabilities of ^Ru
- BROAFERENCE : CONTENTS INDEXING BASED ON FACIAL EXPRESSIONS(International Workshop on Advanced Image Technology 2006)
- Automatic Smile Detection System
- Direct Feedback Method for Measuring the Level of Attention of TV Customers
- Direct Feedback Method for Measuring the Level of Attention of TV Customers
- Direct Feedback Method for Measuring the Level of Attention of TV Customers
- Direct Feedback Method for Measuring the Level of Attention of TV Customers
- K-077 TV Rating System Using Facial Expressions
- Measurement of the Thermal Neutron Capture Cross Section and the Resonance Integral of the ^Sr(n, ν)^Sr Reaction
- Production of the Isomeric State of ^Cs in the Thermal Neutron Capture Reaction ^Cs(η, γ)^Cs
- Temperature Dependence of Isotope Effects of Barium Using a Crown Ether, (II) Barium Isotope Effects in BaCl_2/DC18C6 Systems
- Strontium Isotope Effects in Ligand Exchange Reaction
- Temperature Dependence of Isotope Effects of Barium Using a Crown Ether
- POTENTIATING EFFECT OF PROSTAGLANDINS AND OTHER ANTIULCER DRUGS ON GASTRIC MUCOSAL DEFFENSIVE FACTORS
- EFFECT OF ZOTEPINE ON AFTERDISCHARGE INDUCED BY ELECTRICAL STIMULATION OF AMYGDALOID NUCLEUS IN RATS
- EFFECTS OF ANTI-INFLAMMATORY DRUGS ON TRIPLE VACCINE-INDUCED PLEURISY IN RATS
- DOPAMINE RECEPTOR BLOCKING ACTIVITY OF SULPIRIDE IN THE CANINE EXOCRINE PANCREAS
- EFFECT OF ZOTEPINE AND VARIOUS DRUGS ON APOMORPHINE- AND METHAMPHETAMINE-INDUCED ROTATIONAL BEHAVIOUR IN RATS WITH UNILATERAL LESIONS OF THE SUBSTANTIA NIGRA
- AMINES AND THE RAT EXOCRINE PANCREAS: (3) EFFECTS OF AMINES ON PANCREATIC SECRETION
- INTERACTION BETWEEN ASPIRIN AND PROSTAGLANDINS IN THE ISOLATED GUINEA-PIG TRACHEAL MUSCLE
- RELAXANT EFFECT OF ASPIRIN-LIKE DRUGS ON ISOLATED GUINEA PIG TRACHEAL CHAIN
- Ultrastructure in crushed unmyelinated nerve fiber of streptozotocin-induced diabetic rats (NEREVOUS SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Extraction Behavior of Antimony in a TRUEX System
- Solubility Product of Hexavalent Uranium Hydrous Oxide
- Isotope Effects of Hafnium in Solvent Extraction Using Crown Ethers
- A Study of Methods for Easy Reuse of Existing Content (Content Processing and Information Security)(International Workshop On Advanced Image Technology (IWAIT2004))
- THE CENTRAL ANTI-SEROTONIN ACTIVITY OF ZOTEPINE, A NEW NEUROLEPTIC, IN RATS
- EFFECT OF ZOTEPINE ON HEAD-TWITCH INDUCED BY L-5-HYDROXYTRYPTOPHAN, MESCALINE AND 2, 5-DIMETHOXY-4-METHYLAMPHETAMINE IN MICE AND RATS
- DOPAMINE RECEPTOR BLOCKING ACTIVITY OF SULPIRIDE IN THE CENTRAL NERVOUS SYSTEM
- JISCARD GUI, A Graphical Interface Application for Simple and Quick Calculation of Aviation Route Doses
- Neutron-capture cross-sections of ^Cm and ^Cm measured with an array of large germanium detectors in the ANNRI at J-PARC/MLF
- Effects of acetyl-L-carnitine on the brain lipofuscin content and emotional behavior in aged rats.
- Hair Magnesium, But Not Serum Magnesium, Is Associated With Left Ventricular Wall Thickness in Hemodialysis Patients
- Effect of long-term dosing with tiapride on brain dopamine receptors and metabolism in rats. Comparative study with sulpiride and haloperidol.
- The hypotensive effect of 2-(5-chloro-2-phenoxyanilino)-2-imidazoline (FR35447).
- Effect of zotepine on fenfluramine-induced hyperthermia in rats.
- Electronic Absorption Spectra of U(IV) in Molten LiCl-SrCl2 and CsCl-SrCl2
- Comparative study of tiapride and neuroleptics with anti-dopamine activity on convulsive seizure in mice.
- A Novel Synthesis of L-Pipecolic Acid