THE CENTRAL ANTI-SEROTONIN ACTIVITY OF ZOTEPINE, A NEW NEUROLEPTIC, IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
2-Chloro-11-(2-dimethyl-aminoethoxy) dibenzo [b, f] thiepin (zotepine) is a new neuroleptic drug which is structurally different from known neuroleptics. Zotepine, chlorpromazine, propericiazine, and cyproheptadine inhibited hyperthermia induced by dosing with fenfluramine in rats in a warm environment (26—28°C). Fenfluramine is known to induce hyperthermia by mediation of central serotonin. Zotepine had a 10 times or greater potency than chlorpromazine, propericiazine and cyproheptadine in inhibiting the hyperthermia. Thioridazine did not inhibit the hyperthermia, whereas haloperidol accelerated the hyperthermia. Zotepine was also the most potent inhibitor of <SUP>3</SUP>H-serotonin binding to rat cortical synaptosomes <I>in vitro</I>. However, cyproheptadine had the strongest antiserotonin activity in rat fundus preparations, while zotepine and other neuroleptics showed the same order of potency. These results showed that zotepine is a unique neuroleptic with potent central anti-serotonin activity. The central anti-serotonin activity of zotepine is discussed in connection with its lesser extrapyramidal side effects in humans.
- 社団法人 日本薬理学会の論文
著者
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Ono Takaharu
Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Tomoi Masaaki
Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Shimomura K
Department Of Pharmacology Pharmacological Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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SATOH Hisashi
Research Laboratories, Fujisawa Pharmaceutical Co. Ltd.
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SHIMOMURA Kyoichi
Research Laboratories, Fujisawa Pharmaceutical Co. Ltd.
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MORI Jo
Research Laboratories, Fujisawa Pharmaceutical Co. Ltd.
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MOTOYAMA Yukio
Research Laboratories, Fujisawa Pharmaceutical Co. Ltd.
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KATSUKI Shoji
Research Laboratories, Fujisawa Pharmaceutical Co. Ltd.
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HIRAI Osamu
Research Laboratories, Fujisawa Pharmaceutical Co. Ltd.
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TERAI Takao
Research Laboratories, Fujisawa Pharmaceutical Co. Ltd.
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